Endocrine Abstracts

Evaluation of bone quality represents a challenge since the analysis by bone mineral density (BMD), provides useful but incomplete information. New tools are arising, and amog them, TBS is emerging as a new surrogate marker of bone texture and microarchitecture which may be useful to potentially evaluate the risk of bone fracture and can be obtained from already existing BMD scans. Retrospective study of 23 patients with PHH. Clinical, analytical and BMD data were collected fo...

Background: Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) are common disorders with an autoimmune etiology, which are known as autoimmune thyroid diseases (AITD). A specific seasonal pattern of the month of birth has been suggested in several autoimmune disorders, supporting the hypothesis of a link between viral infections and the development of aberrant immune-regulatory mechanisms. However, there are few studies which specifically address this issue in AIT...

Purpose: Although growing evidence supports the role of primary cilia (PC) in the regulation of cancer development, their possible role has not yet been studied in pituitary neuroendocrine tumours (PitNETs). The study of cilia could serve as a diagnostic tool providing new insights into the mechanisms of tumorigenesis and aggressiveness of PitNETs. Methods: A total of 86 patients with PitNETs (28 functioning and 58 non-functioning [NF-PitNETs]) and 12 co...

Introduction: Abnormal glucose metabolism (AGM) is the most common extra-pulmonary comorbidity in people with cystic fibrosis (CF) and has a high negative impact on the underlying disease. Elevated postprandial glucose level is usually the first manifestation, which is traditionally detected by 75-gram oral glucose tolerance test (OGTT). The aim of this study was to evaluate glycemic pattern during continuous glucose monitoring (CGM) in patients with impaired glucose metabolis...

Introduction: Lenvatinib is an oral tyrosine kinase inhibitor (TKI) used for treatment of progressive, clinically significant or symptomatic disease in patients with iodine-refractory differentiated thyroid cancer (DTC).Objective: To describe our clinical experience with lenvatinib in patients with iodine-refractory differentiated thyroid cancer.Methods: Restrospective cohort study of patients with iodine-refractory differentiated ...

Introduction: One of the main difficulties in the study of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is their wide heterogeneity and variable outcome. Several potential influencing factors on patient survival have been recently identified. These factors could help predict patients’ prognosis.Objectives: Analysis of long-term survival of our GEP-NETs cohort according to the presence of metastatic disease, tumor grade, age, sex, tumor fu...

Introduction: Signalling lymphocytic activation molecule SLAMF1 (CD150) is a modulatory receptor expressed in most immune cells. Different data indicate that CD150 is involved in T cell cytokine production, NK cell and CD8 T cell mediated cytotoxicity, and T regulatory (Treg) cell activity. Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function CD150 in lymphocytes subpopulations from p...

Introduction: Angiopoietins (ANG) -1 and 2, their receptor TIE2, and the vascular endothelial growth factor (VEGF) are involved in the process of angiogenesis. However, their role in the pathogenesis and development of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) is not completely understood. In a previous study of 42 patients with GEP-NET, we observed an elevation of these serum markers, especially in those with metastatic disease. The objective of this study was ...

Introduction: Patients with autoimmune thyroid disease (AITD) exhibit aberrant immune-regulatory mechanisms. Galectins (Gal) are a family of glycan-binding proteins, which have been involved in immune regulation. However, the association of Gal with AITD remains unknown. In this study, we evaluated serum Gal-1 and Gal-9 in patients with AITD.Methods: Peripheral blood samples from 31 patients with Graves’ disease (GD) (14 with untreated hyperthyroidi...

First generation somatostatin receptor ligands (SRL) are the first-line drugs in primary acromegaly treatment or after surgical failure in patients with active acromegaly. In previous studies we confirmed the association of the expression of SSTR2, Ki67 and E-cadherin (CDH1) in responsive GH-secreting adenomas response to SRL. Moreover, E-cadherin showed a greater predictive capacity than most of the markers described. Loss of E-cadherin is a typical mark of ...